Chemistry Tutor: Specializing in Biochemistry, Organic Chemistry, Exam Preparation

Simran tutored I.N. on biosynthesis, focusing on polyketides and the Wittig reaction. They reviewed acetyl and malonyl coenzyme A's role in polyketide synthesis, including Claisen condensation, decarboxylation, cyclization, and reductions. They also cover the Wittig reaction, including ylide stability and mechanism. Finally, they practice multiple-choice questions, particularly those related to aldol reactions and benzene mechanisms, and briefly discuss terpenes.

Simran and Raza reviewed terpene, amino acid, and alkaloid biosynthesis in preparation for Raza's exam. They worked through mechanisms and synthesis pathways, focusing on key reactions and intermediates. Simran emphasized understanding the underlying principles for application in exam questions, and Raza was encouraged to reach out with further questions.

Simran tutors I N on organic chemistry and biosynthesis. They cover E1, E2, and E1cB elimination reactions, focusing on mechanisms, stereochemistry, and factors affecting reaction rates. They also review key metabolic pathways (photosynthesis, glycolysis, Krebs cycle), emphasizing oxidation/reduction reactions and the roles of coenzymes like NADH/NAD+ and NADPH/NADP+. The upcoming open-book exam and future meeting times are confirmed.

Simran and Raza reviewed enolate chemistry, biosynthesis pathways including polyketide and fatty acid synthesis, and terpene biosynthesis mechanisms. They practiced identifying isoprene units in terpene structures and discussed the roles of different enzymes and cofactors in these pathways. They will continue with amino acids and alkaloids in the next session.

Simran and Raza reviewed nucleophile hardness/softness in reductions (LiAlH4 vs. Stryker's reagent), aldol reactions (acid/base catalyzed, homo/crossed), and enolate formation/reactions (LDA vs. weaker bases, steric effects). They discussed predicting reaction outcomes based on reagent properties and electrophilic sites. They plan to continue reviewing and cover biosynthesis.

Simran and Raza reviewed alcohol oxidation reactions, covering reagents like PCC, Swern, DMP, TEMPO/Bleach, and MnO2, discussing their mechanisms, advantages, and disadvantages. They then delve into oxidation/reduction concepts, 1,2 vs. 1,4 conjugate reactions, and the Hard and Soft Acid Base (HSAB) theory, explaining how nucleophile/electrophile hardness influences reaction outcomes. They analyzed examples of Grignard and organocuprate reactions with alpha-beta unsaturated carbonyl compounds, and plan to continue with hydride reducing agents in the next session.